T helper 2 differentiation is necessary for development of lymphedema
نویسندگان
چکیده
منابع مشابه
Listeria arpJ gene modifies T helper type 2 subset differentiation.
BACKGROUND Although the T-cell subset differentiation pathway has been characterized extensively from the view of host gene regulation, the effects of genes of the pathogen on T-cell subset differentiation during infection have yet to be elucidated. Especially, the bacterial genes that are responsible for this shift have not yet been determined. METHODS Utilizing a single-gene-mutation Lister...
متن کاملExtracellular signal-regulated kinase 2 is necessary for mesoderm differentiation.
The extracellular signal-regulated kinase (ERK) is a component of the mitogen-activated protein kinase cascade. Exon 2 of erk2 was deleted by homologous recombination and resulted in embryonic lethality at embryonic day 6.5. erk2 mutant embryos did not form mesoderm and showed increased apoptosis but comparable levels of BrdUrd incorporation, indicating a defect in differentiation. erk2 null em...
متن کاملT-cell differentiation: Commitment factors for T helper cells
The immune system is designed to eradicate a large variety of invading pathogens with minimum immunopathology. T helper cells, also known as CD4+ T cells, may be subdivided into the T helper 1 (Th1) and the T helper 2 (Th2) subsets, which produce distinct profiles of cytokines [1,2]. These Th1 and Th2 cells have opposing roles, regulating immune responses to intracellular and extracellular path...
متن کاملModel Analysis of Helper T Cell Differentiation
Helper T (Th) cells regulate immune responses by producing various cytokines upon antigen stimulation. Helper T cells can be divided into two subsets, Th1 and Th2 [2]. The Th1 cells are responsible for defense against infectious intracellular microorganisms. The Th2 cells are responsible for defense against extracellular pathogens and the development of allergic immune reactions. The SOCS famil...
متن کامل“Rhetoric Teaching” is necessary for all of the university students?
A simple search for information sources shows that there are many researches and articles in the field of lecture method and comparison with other types of teaching methods. Interestingly enough, if not with certainty in all of these researches, at least in most of them, the result was in favor of non-lecturing. Previously, the authors emphasized the importance of rhetoric in a Persian letter (...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Translational Research
سال: 2019
ISSN: 1931-5244
DOI: 10.1016/j.trsl.2018.12.003